Post by partimefriend on Sept 13, 2019 19:08:45 GMT -5
I was going to post this on Yahoo but people get way to wound up over this kinda stuff , you need to do your DD and make your own judgments. 
So i saw a graph posted on Tweeter. It shows two graphs one is ARWR and SLN For LPA.
The graphs came from Silence Therapeutics R&D Day Sept 12 2019, Page 11. www.silence-therapeutics.com/media/1968/sln_rd-day_2019-slides.pdf
Here is the Where the graph can be found from ARWR. Scientific Sessions AHA Page 10. ir.arrowheadpharma.com/static-files/03dc5247-d4cd-47ca-b94d-53608d35d73c
Now the graphs don't lie, BUT a couple things that come to mind. (1) We don't know that silence used the same mice model as ARWR.
(2) It is highly likely that this trigger was optimized further before Amgen took delivery.
PAGE 12
Summary: From ARWR SESSIONS.
• Screening of LPA RNAi triggers in Lp(a) Tg mice identified several that >>>>>>This Shows they are Screening Triggers
induced substantial and sustained knockdown of serum Lp(a) levels
• SAR studies identified a lead RNAi trigger that exhibited >98% maximal>>>>>>Just shows they found the Lead trigger does not mean this is the fully Optimized trigger Amgen received
knockdown after a single 3 mg/kg SQ dose in Tg mice
• NHPs treated with 3 weekly 3 mg/kg SQ RNAi trigger doses resulted in 85- 90% reduction in serum Lp(a) with >1 month duration of effect
So i saw a graph posted on Tweeter. It shows two graphs one is ARWR and SLN For LPA.
The graphs came from Silence Therapeutics R&D Day Sept 12 2019, Page 11. www.silence-therapeutics.com/media/1968/sln_rd-day_2019-slides.pdf
Here is the Where the graph can be found from ARWR. Scientific Sessions AHA Page 10. ir.arrowheadpharma.com/static-files/03dc5247-d4cd-47ca-b94d-53608d35d73c
Now the graphs don't lie, BUT a couple things that come to mind. (1) We don't know that silence used the same mice model as ARWR.
(2) It is highly likely that this trigger was optimized further before Amgen took delivery.
PAGE 12
Summary: From ARWR SESSIONS.
• Screening of LPA RNAi triggers in Lp(a) Tg mice identified several that >>>>>>This Shows they are Screening Triggers
induced substantial and sustained knockdown of serum Lp(a) levels
• SAR studies identified a lead RNAi trigger that exhibited >98% maximal>>>>>>Just shows they found the Lead trigger does not mean this is the fully Optimized trigger Amgen received
knockdown after a single 3 mg/kg SQ dose in Tg mice
• NHPs treated with 3 weekly 3 mg/kg SQ RNAi trigger doses resulted in 85- 90% reduction in serum Lp(a) with >1 month duration of effect