DPC

[qbeing1010]

With all this talk about DPC, DPC 2.0, and SubQ, I'm a little confused. Is ARWR continuing to improve upon DPC as they go along, or is it already optimized as far as it can be (the IV version, such as they are using in current trials)?

And then subcutaneous is something else altogether?  I know that it's given via a shot, and seems to increase the KD time vs. IV.

Is SubQ a better, stronger method that will eventually replace the IV DPC?

[mudbug021]

SubQ is more for the convince of the patient. IE a 30 second shot or pill vs a 30 minute (or longer) drip from an IV.

Is ARWR improving DPC is a trickier answer. It is both Yes and No. Every time they go to a new organ or target area it can be considered an improvement. Can they improve DPC to be better than what it is? I think only a researcher from ARWR can answer that.

What could be improved with DPC, IMHO, 100% of the DPC gets to the targeted area. At the moment I think only 80% gets to the target area the other 20% ends up in the kidneys (or pancreas?... I forget atm.) 85% gets to the liver, the other 15% goes to the spleen. (went back and checked the video around the 28 min mark to check the info) The underlying fact is, they are still seeing high KD numbers. The question remains, is it possible to get better than 80% 85%? I just dont know.  

Another improvement I could see happening is a possible time delay release DPC system. IE One shot slowly releasing its payload that last 6 months to a year before having to receive another shot. But, because I am not a researcher or a bio-chemist. I dont know the ramifications of what all is needed to go into something like that. Admittedly that is a wishful thinking situation.