Manetta & Friend

[qbeing1010]

End2war posted this on YMB:

This is what ARWR says in their slide 8:

"Evidence for immune re-activation in two
chimps with chronic dosing
• 2 of 4 HBeAg positive chimps developed evidence
on biopsy of cytokine activation in the pattern
expected for immunological de-repression
• One of these chimps had an on-treatment flare
and shows ongoing viral suppression following
withdrawal of all therapy

Immune re-activation will be presented in detail
at HepDart in December"

Can someone explain in layman's terms what some of that jargon means?  Thanks.

[mudbug021]

End2war elaborated in more detail on the YMB if you still need more information.

Here is my cliff-note explination...

Of the 4 chimps that are specifically HbeAG positive (Hepatitis B e-Antigen Positive) , 2 of them has shown their immune system working to control the HBV virus. One of the chimps is showing its immune system has continued working well after the treatment has ended. This indicates a possible Functional Cure.

Even though this is excellent news, time is still required for confirmation. As T2S has mentioned a true FC is 6 months or longer.

[labwd1]

Mud
Where are we on the six month timeline? When did the "clock" start?

Thanks!

[mudbug021]

Dec 6, 2015 0:01:28 GMT -5 labwd1 said:

Mud
Where are we on the six month timeline? When did the "clock" start?

Thanks!

That is a very good question. With the available information, your guess is as good as mine.

My best guess(and I emphasis its a guess!)  approximately 45 days prior to data given on AASLD date and then add the time accordingly.

The issue is, I could state "approximately xx amount of days"  and there is no way of knowing if its true or not.  The point is, use your best judgement here. Just for the fact I dont know.