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Arrowhead - Press Releases and SEC Filings	Chart:	Clinical Trials:	Goals for 2016:	C. Anzalone on CNBC:	What is RNAi ?

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About Arrowhead Arrowhead Pharmaceuticals is a biopharmaceutical company developing targeted RNAi therapeutics.
Targeting Innovation
Arrowhead Pharmaceuticals develops novel drugs to treat intractable diseases by silencing the genes that cause them. Using the broadest portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. Arrowhead’s most advanced drug candidate in clinical development is ARC-520, which is designed to treat chronic hepatitis B infection by inhibiting the production of all HBV gene products. The goal is to reverse the immune suppression that prevents the body from controlling the virus and clearing the disease. Arrowhead’s second clinical candidate is ARC-AAT, a treatment for a rare liver disease associated with a genetic disorder that causes alpha-1 antitrypsin deficiency.

Lead Products
ARC-520 is an RNAi-based therapeutic designed to treat chronic hepatitis B virus (HBV) infection. It is the first clinical-stage drug candidate from Arrowhead’s Dynamic Polyconjugate® delivery platform. It is designed to treat chronic HBV infection by reducing the expression and release of new viral particles and key viral proteins with the goal of achieving a functional cure for HBV.

ARC-AAT is a novel unlocked nucleobase analog (UNA)-containing RNAi-based therapeutic for the treatment of liver disease associated with Alpha-1 Antitrypsin Deficiency (AATD), a rare genetic disease that can severely damage the liver and lungs of affected individuals. The goal of treatment with ARC-AAT is to reduce the production of the mutant Z-AAT protein to prevent and potentially reverse accumulation-related liver injury and fibrosis.

The companys pre-clinical stage drug candidates include ARC-521, an RNAi-based therapeutic for the treatment of chronic hepatitis B virus; ARC-F12, an RNAi-based therapeutic to treat hereditary angioedema and thromboembolic diseases; ARC-HIF2, an RNAi-based therapeutic to treat renal cell carcinoma; and ARC-LPA, an RNAi-based therapeutic for the treatment of cardiovascular diseases. It also holds patents related to Adipotide for the treatment of obesity and related metabolic disorders. The company has research collaboration and license agreement with Shire AG to develop and commercialize targeted peptide-drug conjugates.

Platform Delivery Technology
The Dynamic Polyconjugate (DPC®) platform is an RNAi delivery system that has been demonstrated to preferentially deliver to hepatocytes, induce efficient endosomal escape, promote high levels of gene knockdown in multiple animal models, and appears to be well tolerated using a variety of RNAi trigger molecules. It is a modular system that can be optimized on a target-by-target basis and may be targeted in the future to address multiple organ systems and cell types.

Pipeline Development Strategy
Arrowhead’s internal drug pipeline is intended to drive value directly through the clinical development of novel therapeutics and to provide proof of concept for our platform technologies. In addition to our two lead product candidates, ARC-520 and ARC-AAT, we intend to nominate additional clinical candidates that utilize the DPC delivery system. Our core areas of focus for expanding our internal pipeline of RNAi therapeutics are: (1) develop intravenous (IV) administered liver-targeted candidates; (2) develop subcutaneously administered liver-targeted candidates; and (3) explore extra-hepatic targets, including oncology.

To learn more about Arrowhead visit the company's website at: http://arrowheadpharma.com/

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ARWR New Member

Posts: 1
ARWR shares held: 22,300

Registered: Dec 4, 2015 10:21:33 GMT -5

New Member Dec 15, 2015 13:07:34 GMT -5 Think2Succeed likes this

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Post by tntnorman on Dec 15, 2015 13:07:34 GMT -5

Posted a few times on Yahoo, and getting tired of the idiots on there. Looking forward to more civilized discussions here.

I am like most long investors, this company is on the verge of greatness. I just can't explain the stock price. I am confident in our future though and am holding strong.

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Think2Succeed
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Sentiment: Strong buy !

Posts: 182
ARWR shares held: 20,000

Registered: Nov 24, 2015 2:03:46 GMT -5

New Member Dec 15, 2015 14:14:12 GMT -5 tntnorman likes this

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Post by Think2Succeed on Dec 15, 2015 14:14:12 GMT -5

Welcome to the new ARWR board tntnorman !

The fact that YMB is not moderated (besides the lack of essential features for a 21st century message board like posting a simple link or a pic. etc) is exactly what motivated me to create this board....and I'm sure many other longs feel just like you and me.

Yes, many of us can't explain the stock price...there are so many theories (like manipulations to accumulate shares, shorts controlling the price, no FC showed yet, too far from approval etc.) but what matters in the end is the science and its progress and if Arrowhead continues to deliver on the scientific front the stock price is going to follow sooner or later...nobody knows when or what is going to trigger it but nobody can't fight great science for long and RNAi is the next big thing in medicine (now that the delivery puzzle has been solved) for many years from now imo.

T2S

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